Adaptogenic activity of Solanum xanthocarpum with comparative study of marketed formulation. The plant was investigated for its Adaptogenic activity by using three pharmacological models i.e. forced swimming stress test, milk induced leucocytosis and pollution induced immunosuppression. The control group rats swam for 69.5 min (mean) where us the standard and drug treated group of rats swam for 128.5 min and 111.5 minutes respectively. The drug treated rats showed significant increase in swimming time and registered an increase in swimming time of more than 42 min (total) over the control group. Similarly ethanolic extract of plant was subjected for another test i.e. milk induce leucocytosis by giving Subcutaneously Injection of milk in doses of 4 ml/kg body weight produced a marked and significant increase in the leucocytes count after 24 hour of its administration. After given the ethonolic extract of Solanum xanthocarpum it was seen that the average leukocytes count was markedly controlled from 14770 to 10310, where as the average leucocytes count for standard group was 11420. In pollution induced immunosuppression the extract has given far better results against the oxidative-stress induced by the automobile pollution and the total leucocytes count are near to the normal values observed on day 1st, the extract has shown better activity as compared to standard vitamin E formulation. The results clearly indicate that the swimming time increase in treated group when compare with control and leucocytosis induced by milk injection was significantly inhibited by prior treatment of rats with ethanolic extract of Solanum Xanthocarpum. Similarly, in pollution induced immunosuppression the extract has given far better results against the oxidative-stress induced by the automobile pollution.
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